first_img This finding could mean that the Capitol area generally was contaminated with anthrax, which fits with certain environmental sampling data, or it could mean that some subjects were exposed to the anthrax envelope before it was opened or had contact with those in groups 1 and 2, the article says. The other three groups, enrolled for comparison, were from outside the Capitol area and consisted of (5) 2 people who had contracted anthrax infections as a result of previous attacks in 2001, (6) 12 with no anthrax exposure, and (7) 7 who were unexposed but had previously been vaccinated against anthrax. Among nonimmunized people, anthrax antibodies were found only in those who were in the building at the time of the attack, mostly in those who were in Daschle’s offices (when tested before vaccination). Anthrax was found in the nasopharyngeal samples of slightly less than half (47.5%) of workers in groups 1 and 2, including all 13 who were in the office where the letter was opened and lesser proportions of those in adjoining offices. None of the people outside the building had positive samples. All the volunteers in groups 1, 2, and 3 (those in the building when the letter was opened) were given antibiotic treatment immediately, and 10 of the 20 people in group 4 (those outside the building but in the vicinity) also opted to take antibiotics. In addition, 51 of the 59 people in groups 1 and 2 received 3 doses of anthrax vaccine starting several weeks after the attack. The postexposure 3-dose vaccination schedule was “highly immunogenic,” given that anti-PA antibodies were found in more than 94% of subjects and CMI responses were seen in more than 86%, the researchers write. In other studies, 99% to 100% seroconversion was seen with a preventive 3-dose schedule. The standard anthrax vaccination schedule, used in the US military, involves 6 doses over 18 months. The researchers studied 124 people, divided into seven groups. The first four groups consisted of (1) 28 people who were in or near Daschle’s office and had positive nasopharyngeal cultures for anthrax, (2) 31 who were in or near the office but had negative cultures, (3) 24 who were elsewhere in the Hart Senate Office Building, and (4) 20 who were outside the building but in the Capitol area (and were presumed to be unexposed). Scientists who prospectively studied people who were in the vicinity when the letter was opened report that even people who were outside the building showed immune responses to anthrax, suggesting that the deadly spores spread more widely than expected. The letter was one of several mailed to two US senators and several media offices in the fall of 2001, resulting in 22 cases of anthrax, 5 of them fatal. Two tests (enzyme-linked immunosorbent assay and fluorescence-activated cell sorting) were used to examine the subjects’ antibody and cell-mediated immune (CMI) responses to two anthrax proteins: protective antigen (PA) and lethal factor (LF). They conclude that antibiotic treatment protected the infected subjects, who were generally young, from becoming clinically ill. “We do not know whether higher exposure could result in clinical disease even with antibiotics or what happens in immunocompromised or immunologically immature populations,” they state. “Despite postexposure prophylaxis with antibiotics, inhalation of B[acillus] anthracis spores resulted in stimulation of the immune system and possibly subclinical infection, and the greater the exposure, the more complete the immune response,” says the report by Denise L. Doolan of the Naval Medical Research Center in Silver Spring, Md., and associates from there and several other institutions. “Our data demonstrate that exposure to B. anthracis spores primed antibody and cellular responses in a dose-dependent and antigen-specific manner in immunized and unimmunized subjects, enhanced AVA-boost responses, and boosted recall responses in previously immunized subjects,” the researchers write.center_img No significant differences in symptoms were seen between subjects with and without anthrax exposure and with and without immune responses, except for headache, which was more common in exposed people but correlated with the duration of antibiotic use. Jan 10, 2007 (CIDRAP News) – The anthrax-laced letter sent to Sen. Tom Daschle’s office in 2001 may have affected more people than was recognized at the time, but the antibiotics and vaccinations given to potentially exposed people were highly effective, according to an immunologic study of the event. See also: The researchers, writing in the Journal of Infectious Diseases, also report that those who were exposed showed immune responses to anthrax even though they were immediately put on preventive antibiotic treatment. Further, they found that 3 doses of anthrax vaccine adsorbed (AVA)—versus the standard 6-dose regimen—triggered a strong immune response in those who were vaccinated after the attack. The researchers also report an inverse relationship between CMI responses and antibiotic treatment, which suggested that the treatment impeded anthrax spore germination, the report says. In the previously vaccinated volunteers—who were revaccinated during the study—immune responses were strong even after a single new dose of vaccine. Doolan DL, Freilich DA, Brice GT, et al. The US Capitol bioterrorism anthrax exposures: clinical epidemiological and immunological characteristics. J Infect Dis 2007 Jan 15;195(2):174-84 [Full text] In the tests for CMI, the researchers found a direct relationship between presumed anthrax exposure and response rate. Unexpectedly, however, they found evidence of CMI in some people who were outside the building (group 4). For example, monocytic responses were detected in more than 70% of groups 1 and 2, 37.5% of group 3, and 30% of group 4. Monocytic responses for group 4 were significantly higher than those for unexposed controls (group 6). Hadler JL. Learning from the 2001 anthrax attacks: immunological characteristics. (Editorial) J Infect Dis 2007 Jan 15;195(2):163-4 [Full text] The data suggest, they add, that low-level anthrax exposure induces asymptomatic cellular immune responses without antibodies and that intermediate exposure induces both cellular and antibody responses.last_img read more

first_imgWillian will join Arsenal this weekend (Picture: Getty)Former Chelsea winger Willian stands to earn £35million over three years at Arsenal after agreeing a deal with the Gunners that will effectively see him earn £220,000-a-week.The Gunners expect to announce the capture of the 32-year-old this weekend following Willian’s exit from Chelsea this week.Willian had been happy to stay at Stamford Bridge but the Blues were unwilling to hand him the three-year deal he craved.Arsenal were willing to do so and the Gunners agreed a basic salary with Willian of around £100,000-a-week, which is a dip on the £120,000-a-week he earned in west London.ADVERTISEMENTHowever, the Daily Mail claim that Willian was persuaded to join the Gunners after the offer of a huge signing-on fee that will significantly boost his basic weekly salary. Advertisement Metro Sport ReporterThursday 13 Aug 2020 10:55 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link6.7kShares Willian will sign a three-year deal with the option of a fourth year (Picture: Getty)Once this figure is taken into account alongside other ‘loyalty’ bonuses and appearance fees, it’s claimed Willian will earn around £220,000-a-week.AdvertisementAdvertisement‘He would have got nowhere near that money at Chelsea,’ a source told the Mail.‘The signing-on fee reflects that it is a free transfer and if he sees out the duration it’s a great deal for him.’That would make him the second highest earner at the club behind Mesut Ozil and the deal raises question marks over Arsenal’s recent decision to make 55 employees redundant.The news was widely criticised and it’s even claimed Arsenal pushed back the announcement of Willian’s arrival as it reflected poorly on the club. Even more bizarrely is the claim that the 32-year-old’s deal will include the option of a fourth year and the deal is bound to raise eyebrows.More: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man CityMikel Arteta is likely to offload a number of fringe players following Willian’s arrival in a bid to balance the books.The Spaniard has been told he must sale before he can but this summer and the likes of Mesut Ozil, Matteo Guendouzi, Sead Kolasinac, Ainsley Maitland-Niles and Rob Holding have been put up for sale.Should the Gunners make a number of sales, they will reconsider their indifference at paying the £45m release clause in Thomas Partey’s contract at Atletico Madrid.The Gunners had decided against doing so, preferring to offer the likes of Guendouzi in exchange instead.But their budget this summer is dependent upon the amount of players they can sale. MORE: West Ham set asking price for Chelsea to sign Declan Rice View 8 comments Advertisement Willian to earn £35m at Arsenal after agreeing eye-watering £220,000-a-week deallast_img read more

first_imgARC Fiduciary has launched an Energy Transition Opportunity Fund, which will invest in infrastructure projects focusing on the transition from fossil fuel to renewable energy in the US.Ingram started his career as a specialist in sustainability and private markets at APG in Amsterdam.He has also served as chairman of APG working group Principles for Responsible-Investment Hedge Funds, as well as manager of APG’s Opportunities Fund.Dempsey Gable, co-manager of ARC’s climate fund, has also managed the same fund at APG.APG said it had not yet appointed Ingram’s successor and that his tasks had been divided across the organisation.It added that it was too early to say whether it would commit assets to Ingram’s new funds. Paulus Ingram, head of hedge fund investing at APG, has left the Dutch asset manager to co-found a US-based institutional manager focusing on sustainable investing.The new company, ARC Fiduciary, will seek to achieve financial outperformance while contributing to the United Nations Sustainable Development Goals.Ingram, who has worked at APG since 2010, operated from the company’s New York office, where he was responsible for more than €25bn in hedge fund holdings.He pointed to a “considerable” lack of sustainable-investment opportunities for large institutional investors and said many pension funds wanted to reduce their carbon footprint significantly.last_img read more

first_imgThe deck area of the pontoon being proposed would be more than three times as big as BCC’s current “acceptable outcome”, according to the application, 84sq m instead of 25sq m. As well, the length of the pontoon (28m) would be about three times that of the current 10m length “acceptable”. Queensland’s richest man is looking to put in one of the biggest private jetties the city has seen at his home in Fig Tree Pocket. Picture: Steve Pohlner.Queensland’s richest man Clive Palmer has asked for special permission to build one of Brisbane’s largest private home jetties to moor his yacht by his riverside mansion.Records show his builders Coastal Pontoon & Jetty Repairs asked Brisbane City Council for a development permit for “tidal works” at Palmer’s Fig Tree Pocket home – but “the proposed pontoon is significantly larger that the dimensions and areas” that BCC considers acceptable. Quade Cooper finally sells off Bulimba pad A file photo from four years ago when “Maximus” was moored next to Clive Palmer’s mansion on Sovereign Island on the Gold Coast. Picture: Lyndon MechielsenMr Palmer’s property has 131.5m river frontage, it said, and currently has “a rock revetment wall and a boat ramp and an existing pontoon”.More from newsParks and wildlife the new lust-haves post coronavirus9 hours agoNoosa’s best beachfront penthouse is about to hit the market9 hours ago“As part of the proposal the existing pontoon will be replaced by two pontoons placed side-by-side (double pontoon).”The application acknowledged that “the proposal cannot meet AO2.1 of the code” but argued it met performance outcomes.Mr Palmer bought the Fig Tree Pocket home for $7.5m – a $2m discount on the listed price – off Linc Energy founder, Peter Bond, in 2018, and has since set about turning it into one of the best homes in Brisbane. FOLLOW SOPHIE FOSTER ON TWITTER Video Player is loading.Play VideoPlayNext playlist itemMuteCurrent Time 0:00/Duration 0:58Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:58 Playback Rate1xChaptersChaptersDescriptionsdescriptions off, selectedCaptionscaptions settings, opens captions settings dialogcaptions off, selectedQuality Levels720p720pHD432p432p216p216p180p180pAutoA, selectedAudio Tracken (Main), selectedFullscreenThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.This is a modal window. This modal can be closed by pressing the Escape key or activating the close button.Close Modal DialogThis is a modal window. This modal can be closed by pressing the Escape key or activating the close button.PlayMuteCurrent Time 0:00/Duration 0:00Loaded: 0%Stream Type LIVESeek to live, currently playing liveLIVERemaining Time -0:00 Playback Rate1xFullscreenHow much do I need to retire?00:58center_img Clive Palmer has been busy turning his Fig Tree Pocket home into one of Brisbane’s best. Picture: Steve Pohlner.The application said “the proposal seeks approval to replace the existing pontoon attached to the premise and add a second pontoon deck to create a longer structure to accommodate the private vessel used by (Mr Palmer)”.It said “the pontoon has been designed to accommodate the landowner’s private vessel which has a maximum length of 23m, 5.5m width and 1.6m depth”.The last anyone heard of Mr Palmer’s most famous vessel – Maximus II – was when it was put on the market in San Diego mid-2019 for $US3.275m. Maximus II is 32.31m, and thus longer than the 28m one that the development application refers to. Hands-free homebuying, gloves, set to be the norm MORE: Darius Boyd sells Brisbane homelast_img read more

first_imgThe facility being built on a 759.6 square-meter lot has two isolation buildings and four buildings for persons under investigation. San Carlos City in Negros Occidental is building its own facility for coronavirus disease 2019 in the vicinity of the city’s sports complex in Barangay Rizal. According to Mayor Renato Gustilo, they decided to construct one with a budget of P10 million as they can no longer use schools as quarantine facilities when classes start. SAN CARLOS CITY, NEG. OCC.-LGU INFORMATION PAGE Mayor Renato Gustilo said on Wednesday the city government decided to have one as school buildings can no longer be used as quarantine facilities once classes start. “The Phase 1 of the temporary COVID-19 facility is almost finished,” said the mayor.He inspected the construction site on July 27. San Carlos City has 21 confirmed cases as of Tuesday and recorded this province’s first COVID-19 death recently. He was confined in the Intensive Care Unit of a tertiary government hospital in this city, it added. Investigation of the Local Contact Tracing Team headed by the City Health Office showed that the patient was brought to San Carlos City Hospital on July 20. The patient was intubated and stabilized before he was referred to a hospital here on July 22. The fatality was a 77-year-old man from Barangay 6 who succumbed to complications around 5:50 p.m. on Monday, the city government said on its Facebook post. The fatality worked as ferry boat captain of a shipping line operating across the ports of San Carlos City and Toledo City in Cebu. (With a report from PNA/PN) Project engineer Jasper John Lampute said the construction is now 80 percent complete. The COVID-19 facility is being funded through the city’s 20 percent development fund under the construction development of the hospital/anti-COVID-19 program. On July 24, his reverse transcription-polymerase chain reaction test yielded a positive result. BACOLOD City – The City of San Carlos in this province is constructing its own coronavirus disease 2019 (COVID-19) facility in the vicinity of the city’s sports complex in Barangay Rizal with a budget of P10 million.last_img read more

first_imgThe EC AquaTrojans remain undefeated facing the Knights of South Dearborn at home on Tuesday night.  EC girls won 140-18 while the EC boys were victorious 140-33.Individual winners include Ray Krider-200 Freestyle; Kyra Hall-200 IM, 100 Backstroke; Jacob Weber-200 IM, 100 Freestyle;  Olivia Nixon-50 Freestyle; Ethen Witte-50 Freestyle; Aly Bailey-1 meter diving; John Crawley-1 meter diving; Mackenzie Schantz-100 Fly, 500 Freestyle; Matt Badinghaus-100 Fly; Caroline Walters-100 Freestyle; Jackson Ketcham-500 Freestyle; Evan Ludwig-100 Backstroke; Jordan Marro-100 Breaststroke.EC won all 6 relays.EC hosts the Milan Indians on Teacher Appreciation Night.  The festivities begin at 5:30 PM.Go AquaTrojans!!Courtesy of AquaTrojans Coach Brandon Loveless.last_img read more

first_img “And then you can see that [Anthony] Martial was firing on all cylinders, same as [Mason] Greenwood, so there was no way Ole was going to drop any of those guys for Ighalo. read also:Ighalo has no interest in Paris Saint-Germain’s transfer speculations “But where I will fault Ole is that even when these guys are not meeting up in some games, I think he should have tried Ighalo. “It wasn’t really nice that a player’s contract was renewed and you didn’t even allow him to play up to 20 minutes of any Premier League game. That is not encouraging. It makes a player lose all the confidence he has built over time.” FacebookTwitterWhatsAppEmail分享 Former Nigeria forward, Victor Ezeji, is not impressed with the usage of Odion Ighalo at Manchester United. The 31-year-old front-man showed promise during his initial loan spell at United last season. But the Nigerian has not found much game time since the Premier League Project Restart, and Ezeji hopes Solskjaer gives him more chances. “Every coach believes in his starting XI and to be very fair to Ighalo, the Covid situation did not help him, because if not for Covid, [Marcus] Rashford would still have been out until the end of the season,” Ezeji told Goal.com. “And when Rashford recovered, because of the belief Ole has in Rashford, he had to bring him back into the team.Advertisement Promoted Content10 Risky Jobs Some Women DoAwesome But Ridiculously Expensive Things Bought By Keanu ReevesProbably The World’s Most Beautiful Ceilings!This Guy Photoshopped Himself Into Celeb Pics And It’s HystericalWhat Happens To Your Brain When You Play Too Much Video Games?7 Ways To Understand Your Girlfriend Better11 Most Immersive Game To Play On Your Table Top5 Of The World’s Most Unique Theme Parks7 Black Hole Facts That Will Change Your View Of The Universe7 Ways To Understand Your Girlfriend BetterWho Is The Most Powerful Woman On Earth?10 Amazing Characters We Wish Were Official Disney Princessescenter_img Loading… last_img read more

first_imgKing led all 25 laps of Saturday’s IMCA RaceSaver Sprint Car Lawanda Cogburn Scorekeeper Memorial at 105 Speedway after breaking in hot laps and borrowing a driveshaft from Kent Lewis Sr.  Feature results – 1. Daniel King; 2. Isaiah Garcia; 3. Rod Craddock; 4. Trey Schmidt; 5. Tyler Harris; 6. Caleb Padgett; 7. Matt Migl; 8. Chris Hinsen; 9. Mark Harris; 10. Kent Lewis Sr.; 11. Aiden Welch; 12. Billy Cramer; 13. Les Leaton; 14. William Reed; 15. Jacob Har­ris; 16. Steve Holland; 17. Steve Leggio; 18. Gordon Taylor; 19. Austin Smith; 20. Mike Gabriel; 21. Dustyn Welch. CLEVELAND, Texas (July 4) – Daniel King had his quick thinking crew to thank for his first Southern United Sprints feature win of the season. Daniel King won for the second time in three Southern United Sprint starts this season, leading every lap of Saturday’s Lawanda Cogburn Scorekeeper Memorial at 105 Speedway. (Photo by Ron Skinner) He had his competition to thank for his second. center_img Lewis, Trey Schmidt and a host of King’s fellow drivers helped him get back on track for the heat. He finished second in that race, then started outside the front row in the feature and ran in lapped traffic much of the way but was not challenged  King had been the series’ opening night winner after his crew jury rigged his car with bungee cord to keep it in gear. Isaiah Garcia, Rod Craddock, Schmidt and Tyler Harris rounded out the top five. last_img read more

first_imgRelatedPosts Mike Tyson comeback fight postponed WBA Champion Charr to hold Ruiz Jr talks Mike Tyson beats up seven prostitutes American boxing great Mike Tyson has been offered $1 million to have a bout with Sonny Bill Williams, Paul Gallen or Barry Hall, according to the Australian Daily Mail.The 53-year-old went viral earlier this week, with a video emerging on YouTube of him sparring and looking in top shape, fuelling rumours that he was considering a return to the ring for a series of three-round charity matches. Now, it is understood Australian promoter Brian Amatruda has put in a $1 million bid for him to fight one of three sports stars.Williams has an impressive boxing record, winning all seven of his bouts so far, including three knockouts.Former Cronulla Sharks captain Paul Gallen and ex-Australian Rules star Barry Hall were among the other names being considered.Amatruda told the Australian Daily Mail: “I’d hold it at Melbourne Arena where we’d get over 10,000 or even Princes Park where they got 30,000 for Jeff Fenech versus Azumah Nelson.“He might be 53-years-old but he’s still a huge name and any of those blokes Hall, Gallen or Sonny Bill would jump at the chance to get into the ring with him.” Tags: Barry HallBOXINGCharity Matchesmike tysonPaul GallenSonny Bill Williamslast_img read more

first_imgBLUE HILL — Two sets of champions were crowned at Sunday’s Duane B. Gray Memorial Golf Tournament at Blue Hill Country Club.The event, which is held annually for current and former George Stevens Academy students and parents, crowned Rob Clapp, Mark Clapp, Homer Lowell and Ebb Walton as morning champions. Afternoon champions were John Richardson, Ed Volkwein, David Taylor and Percy Zentz.Ben Wootten and Stefan Simmons won individual titles for getting closest to the pin, and Walton, Chris Page, Bonnie Paulas and Phyllis Taylor won longest drive honors.Proceeds from the event went to GSA’s annual fund, which helps fund academic programs, arts, athletics and more at the school.This is placeholder textThis is placeholder textlast_img read more